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1

Clinical significance of half-lives of the tumor markers alpha-fetoprotein and des-γ-carboxy prothrombin after hepatectomy for hepatocellular carcinoma

Tsukamoto, Masayo, Nitta, Hidetoshi, Imai, Katsunori, Higashi, Takaaki, Shigeki, Nakagawa, Okabe, Hirohisa, Arima, Kota, Kaida, Takayoshi, Taki, Katsunobu, Hashimoto, Daisuke, Chikamoto, Akira, Ishiko

Journal:

Hepatology Research

Year:

2017

Language:

english

File:

PDF, 779 KB

english, 2017

2

A Time-Resolved Fluorescence Probe for Dipeptidyl Peptidase 4 and Its Application in Inhibitor Screening

Mitsuyasu Kawaguchi, Dr. Takayoshi Okabe, Takuya Terai, Dr. Kenjiro Hanaoka, Dr. Hirotatsu Kojima, Izumi Minegishi, Prof. Dr. Tetsuo Nagano

Journal:

Chemistry - A European Journal

Year:

2010

Language:

english

File:

PDF, 541 KB

english, 2010

3

A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein–peptide interaction inhibitors

Junko Mikuni, Miki Kato, Shigenao Taruya, Keiko Tsuganezawa, Masumi Mori, Naoko Ogawa, Teruki Honma, Shigeyuki Yokoyama, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Akiko Tanaka

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 509 KB

english, 2010

4

Identification of novel ASK1 inhibitors using virtual screening

Masako Okamoto, Nae Saito, Hirotatsu Kojima, Takayoshi Okabe, Kohsuke Takeda, Hidenori Ichijo, Toshio Furuya, Tetsuo Nagano

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

5

Virtual screening and further development of novel ALK inhibitors

Masako Okamoto, Hirotatsu Kojima, Nae Saito, Takayoshi Okabe, Yoshiaki Masuda, Toshio Furuya, Tetsuo Nagano

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.36 MB

english, 2011

6

Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors

Mitsuyasu Kawaguchi, Takuya Terai, Rei Utata, Miki Kato, Keiko Tsuganezawa, Akiko Tanaka, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 612 KB

english, 2008

7

Synthesis of cadeguomycin (7-deazaguanosine-7-car☐ylic acid)

Tadao Kondo, Toshio Goto, Takayoshi Okabe, Nobuo Tanaka

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 181 KB

english, 1983

8

Peucedanum japonicum Thunb Inhibits High-fat Diet Induced Obesity in Mice

Takafumi Okabe, Takayoshi Toda, Natthanan Nukitrangsan, Masashi Inafuku, Hironori Iwasaki, Hirosuke Oku

Journal:

Phytotherapy Research

Year:

2011

Language:

english

File:

PDF, 225 KB

english, 2011

9

Tumor specific cytotoxicity of β-glucosylceramide: structure–cytotoxicity relationship and anti-tumor activity in vivo

Hirosuke Oku, Changchun Li, Masayuki Shimatani, Hironori Iwasaki, Takayoshi Toda, Takafumi Okabe, Hisami Watanabe

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 835 KB

english, 2009

10

Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives fromToddalia asiaticaLam.

Hironori Iwasaki, Takafumi Okabe, Kensaku Takara, Takayoshi Toda, Masayuki Shimatani, Hirosuke Oku

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 1011 KB

english, 2010

11

Establishment of an indicator cell system for hepatitis C virus

Yoshinori Tanaka, Yoshio Mori, Hideki Tani, Takayuki Abe, Kohji Moriishi, Hirotatsu Kojima, Tetsuo Nagano, Takayoshi Okabe, Tetsuro Suzuki, Masashi Tatsumi, Yoshiharu Matsuura

Journal:

Microbiology and Immunology

Year:

2010

Language:

english

File:

PDF, 1.15 MB

english, 2010

12

BE-23372M, a Novel and Specific Inhibitor for Epidermal Growth Factor Receptor Kinase

Seiichi Tanaka, Takayoshi Okabe, Shinya Chieda, Kaori Endo, Tomoko Kanoh, Akira Okura, Eisaku Yoshida

Journal:

Year:

1994

File:

PDF, 673 KB

1994

13

Improvement of production of Kojic acid by a mutant strain Aspergillus oryzae, MK107-39

Takafumi Futamura, Mitsuyasu Okabe, Takayoshi Tamura, Kyouko Toda, Toshio Matsunobu, Yong Soo Park

Journal:

Journal of Bioscience and Bioengineering

Year:

2001

Language:

english

File:

PDF, 357 KB

english, 2001

14

Kojic acid production in an airlift bioreactor using partially hydrolyzed raw corn starch

Takafumi Futamura, Hironori Ishihara, Takayoshi Tamura, Tetsuya Yasutake, Guowei Huang, Mami Kojima, Mitsuyasu Okabe

Journal:

Journal of Bioscience and Bioengineering

Year:

2001

Language:

english

File:

PDF, 558 KB

english, 2001

15

Hyperbranched Polyglycerol-Grafted Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization, Functionalization, Size Separation, Magnetic Properties, and Biological Applications

Li Zhao, Tokuhiro Chano, Shigehiro Morikawa, Yukie Saito, Akihiko Shiino, Sawako Shimizu, Takuro Maeda, Takayoshi Irie, Shuji Aonuma, Hidetoshi Okabe, Takahide Kimura, Toshiro Inubushi, Naoki Komatsu

Journal:

Advanced Functional Materials

Year:

2012

Language:

english

File:

PDF, 1.88 MB

english, 2012

16

L-152,804: Orally Active and Selective Neuropeptide Y Y5 Receptor Antagonist

Akio Kanatani, Akane Ishihara, Hisashi Iwaasa, Kayo Nakamura, Osamu Okamoto, Masayasu Hidaka, Junko Ito, Takahiro Fukuroda, Douglas J. MacNeil, Lex H.T. Van der Ploeg, Yasuyuki Ishii, Takayoshi Okabe,

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 117 KB

english, 2000

17

A dual inhibitor against prolyl isomerase Pin1 and cyclophilin discovered by a novel real-time fluorescence detection method

Tadashi Mori, Masafumi Hidaka, Yi-Chin Lin, Ibuki Yoshizawa, Takayoshi Okabe, Shinichiro Egashira, Hirotatsu Kojima, Tetsuo Nagano, Mamoru Koketsu, Mari Takamiya, Takafumi Uchida

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 700 KB

english, 2011

18

Development of NIR Fluorescent Dyes Based on Si–rhodamine for in Vivo Imaging

Koide, Yuichiro, Urano, Yasuteru, Hanaoka, Kenjiro, Piao, Wen, Kusakabe, Moriaki, Saito, Nae, Terai, Takuya, Okabe, Takayoshi, Nagano, Tetsuo

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

19

High-Throughput Screening with Quantitation of ATP Consumption: A Universal Non-Radioisotope, Homogeneous Assay for Protein Kinase

Koresawa, Mitsunori, Okabe, Takayoshi

Journal:

Assay and Drug Development Technologies

Year:

2004

Language:

english

File:

PDF, 388 KB

english, 2004

20

Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound

Nakano, Hirofumi, Saito, Nae, Parker, Lorien, Tada, Yukio, Abe, Masanao, Tsuganezawa, Keiko, Yokoyama, Shigeyuki, Tanaka, Akiko, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.78 MB

english, 2012

21

Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe

Kawaguchi, Mitsuyasu, Okabe, Takayoshi, Okudaira, Shinichi, Nishimasu, Hiroshi, Ishitani, Ryuichiro, Kojima, Hirotatsu, Nureki, Osamu, Aoki, Junken, Nagano, Tetsuo

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.42 MB

english, 2013

22

Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness

Hirano, Tamaki, Satow, Reiko, Kato, Asami, Tamura, Mana, Murayama, Yumi, Saya, Hideyuki, Kojima, Hirotatsu, Nagano, Tetsuo, Okabe, Takayoshi, Fukami, Kiyoko

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1000 KB

english, 2013

23

Development of a highly sensitive, high-throughput assay for glycosyltransferases using enzyme-coupled fluorescence detection

Kumagai, Kazuo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo

Journal:

Analytical Biochemistry

Year:

2014

Language:

english

File:

PDF, 2.73 MB

english, 2014

24

P111

Shimamoto, Kazuhito, Hanaoka, Kenjiro, Sasakura, Kiyoshi, Tsuchiya, Yukihiro, Watanabe, Yasuo, Kimura, Hideo, Okabe, Takayoshi, Nagano, Tetsuo, Urano, Yasuteru

Journal:

Year:

2014

Language:

english

File:

PDF, 35 KB

english, 2014

25

Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor

Kawaguchi, Mitsuyasu, Okabe, Takayoshi, Okudaira, Shinichi, Hanaoka, Kenjiro, Fujikawa, Yuuta, Terai, Takuya, Komatsu, Toru, Kojima, Hirotatsu, Aoki, Junken, Nagano, Tetsuo

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 1.64 MB

english, 2011

26

Antiatherosclerotic Function of Kokuto, Okinawan Noncentrifugal Cane Sugar

Okabe, Takafumi, Toda, Takayoshi, Inafuku, Masashi, Wada, Koji, Iwasaki, Hironori, Oku, Hirosuke

Journal:

Journal of Agricultural and Food Chemistry

Year:

2009

Language:

english

File:

PDF, 1.91 MB

english, 2009

27

Sphingosine, a Modulator of Human Translesion DNA Polymerase Activity

Kamath-Loeb, Ashwini S., Balakrishna, Sharath, Whittington, Dale, Shen, Jiang-Cheng, Emond, Mary J., Okabe, Takayoshi, Masutani, Chikahide, Hanaoka, Fumio, Nishimura, Susumu, Loeb, Lawrence A.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 2.58 MB

english, 2014

28

High-Throughput Screening System To Identify Small Molecules That Induce Internalization and Degradation of HER2

Isa, Masayuki, Asanuma, Daisuke, Namiki, Shigeyuki, Kumagai, Kazuo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Hirose, Kenzo

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 915 KB

english, 2014

29

A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors

Fujikawa, Yuuta, Morisaki, Fumika, Ogura, Asami, Morohashi, Kana, Enya, Sora, Niwa, Ryusuke, Goto, Shinji, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Inoue, Hideshi

Journal:

Chemical Communications

Year:

2015

Language:

english

File:

PDF, 665 KB

english, 2015

30

Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport

Terai, Takuya, Kohno, Moe, Boncompain, Gaelle, Sugiyama, Shigeru, Saito, Nae, Fujikake, Ryo, Ueno, Tasuku, Komatsu, Toru, Hanaoka, Kenjiro, Okabe, Takayoshi, Urano, Yasuteru, Perez, Franck, Nagano, Te

Journal:

Journal of the American Chemical Society

Year:

2015

Language:

english

File:

PDF, 1.47 MB

english, 2015

31

Intraoperative blood loss is not a predictor of prognosis for pancreatic cancer

Arima, Kota, Hashimoto, Daisuke, Okabe, Hirohisa, Inoue, Risa, Kaida, Takayoshi, Higashi, Takaaki, Taki, Katsunobu, Nitta, Hidetoshi, Hayashi, Hiromitsu, Chikamoto, Akira, Beppu, Toru, Baba, Hideo

Journal:

Year:

2016

Language:

english

File:

PDF, 481 KB

english, 2016

32

Heat injury to the inferior vena cava by bipolar tissue sealer

Chikamoto, Akira, Kaida, Takayoshi, Arima, Kota, Higashi, Takaaki, Taki, Katsunobu, Ida, Satoshi, Okabe, Hirohisa, Nitta, Hidetoshi, Hayashi, Hiromitsu, Hashimoto, Daisuke, Watanabe, Masayuki, Beppu,

Journal:

Surgical Endoscopy

Year:

2016

Language:

english

File:

PDF, 712 KB

english, 2016

33

The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms

Arima, Kota, Okabe, Hirohisa, Hashimoto, Daisuke, Chikamoto, Akira, Kuroki, Hideyuki, Taki, Katsunobu, Kaida, Takayoshi, Higashi, Takaaki, Nitta, Hidetoshi, Komohara, Yoshihiro, Beppu, Toru, Takeya, M

Journal:

Journal of Gastrointestinal Surgery

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

34

Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent

Nakano, Hirofumi, Hasegawa, Tsukasa, Saito, Nae, Furukawa, Kaoru, Mukaida, Naofumi, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 684 KB

english, 2015

35

Prognostic Impact of Visceral Fat Amount and Branched-Chain Amino Acids (BCAA) in Hepatocellular Carcinoma

Higashi, Takaaki, Hayashi, Hiromitsu, Kaida, Takayoshi, Arima, Kota, Takeyama, Hideaki, Taki, Katsunobu, Izumi, Daisuke, Tokunaga, Ryuma, Kosumi, Keisuke, Nakagawa, Shigeki, Okabe, Hirohisa, Imai, Kat

Journal:

Annals of Surgical Oncology

Year:

2015

Language:

english

File:

PDF, 555 KB

english, 2015

36

Identification and characterization of a novel diacylglycerol kinase α-selective inhibitor, CU-3

Liu, Ke, Kunii, Naoko, Sakuma, Megumi, Yamaki, Atsumi, Mizuno, Satoru, Sato, Mayu, Sakai, Hiromichi, Kado, Sayaka, Kumagai, Kazuo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Shirai, Yasuhito

Journal:

The Journal of Lipid Research

Year:

2016

Language:

english

File:

PDF, 4.51 MB

english, 2016

37

Development of a potent and selective FLT3 kinase inhibitor by systematic expansion of a non-selective fragment-screening hit

Nakano, Hirofumi, Hasegawa, Tsukasa, Imamura, Riyo, Saito, Nae, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 594 KB

english, 2016

38

The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases

Arima, Kota, Okabe, Hirohisa, Hashimoto, Daisuke, Chikamoto, Akira, Tsuji, Akira, Yamamura, Kensuke, Kitano, Yuki, Inoue, Risa, Kaida, Takayoshi, Higashi, Takaaki, Taki, Katsunobu, Imai, Katsunori, Ko

Journal:

International Journal of Clinical Oncology

Year:

2016

Language:

english

File:

PDF, 624 KB

english, 2016

39

An HTRF based high-throughput screening for discovering chemical compounds that inhibit the interaction between Trypanosoma brucei Pex5p and Pex14p

Watanabe, Yuichi, Kawaguchi, Kosuke, Saito, Syuken, Okabe, Takayoshi, Yonesu, Kiyoaki, Egashira, Shinichiro, Kameya, Masafumi, Morita, Masashi, Kashiwayama, Yoshinori, Imanaka, Tsuneo

Journal:

Biochemistry and Biophysics Reports

Year:

2016

Language:

english

File:

PDF, 546 KB

english, 2016

40

Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes

Kimura, Yasuaki, Saito, Nae, Hanada, Kayo, Liu, Jiaan, Okabe, Takayoshi, Kawashima, Shigehiro A., Yamatsugu, Kenzo, Kanai, Motomu

Journal:

Year:

2015

Language:

english

File:

PDF, 967 KB

english, 2015

41

Pre-treatment double- or triple-positive tumor markers are predictive of a poor outcome for patients undergoing radiofrequency ablation for hepatocellular carcinoma

Nitta, Hidetoshi, Nakagawa, Shigeki, Kaida, Takayoshi, Arima, Kota, Higashi, Takaaki, Taki, Katsunobu, Okabe, Hirohisa, Hayashi, Hiromitsu, Hashimoto, Daisuke, Chikamoto, Akira, Ishiko, Takatoshi, Bep

Journal:

Year:

2017

Language:

english

File:

PDF, 795 KB

english, 2017

42

Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma

Higashi, Takaaki, Hayashi, Hiromitsu, Kitano, Yuki, Yamamura, Kensuke, Kaida, Takayoshi, Arima, Kota, Taki, Katsunobu, Nakagawa, Shigeki, Okabe, Hirohisa, Nitta, Hidetoshi, Imai, Katsunori, Hashimoto,

Journal:

Medical Oncology

Year:

2016

Language:

english

File:

PDF, 3.42 MB

english, 2016

43

PGE2 signaling promotes the expansion of ALDH1-positive tumor cells in pancreatic ductal adenocarcinoma

Arima, Kota, Ishimoto, Takatsugu, Okabe, Hirohisa, Kitano, Yuki, Inoue, Risa, Yamamura, Kensuke, Kaida, Takayoshi, Higashi, Takaaki, Taki, Katsunobu, Imai, Katsunori, Hashimoto, Daisuke, Chikamoto, Ak

Journal:

Year:

2016

Language:

english

File:

PDF, 47 KB

english, 2016

44

Cadeguomycin, a novel nucleoside analog antibiotic. I. The producing organism, production and isolation of cadeguomycin.

TANAKA, NOBUO, WU, RONG TSUN, OKABE, TAKAYOSHI, YAMASHITA, HIDE, SHIMAZU, AKIRA, NISHIMURA, TOSHIO

Journal:

The Journal of Antibiotics

Year:

1982

Language:

english

File:

PDF, 3.11 MB

english, 1982

45

Lactoquinomycin B, a novel antibiotic.

OKABE, TAKAYOSHI, NOMOTO, KUNIKO, TANAKA, NOBUO

Journal:

The Journal of Antibiotics

Year:

1986

Language:

english

File:

PDF, 2.09 MB

english, 1986

46

IM8443T substance, an antitumor triene .BETA.-lactone antibiotic.

OKABE, TAKAYOSHI, ISONO, FUJIO, KASHIWAGI, MASAMI, TAKAHASHI, MASAKO, NISHIMURA, TOSHIO, SUZUKI, HIDEO, TANAKA, NOBUO

Journal:

The Journal of Antibiotics

Year:

1985

Language:

english

File:

PDF, 781 KB

english, 1985

47

Enhancement of pyrimidine nucleoside uptake into K562 and YAC-1 cells by cadeguomycin.

WU, RONG TSUN, OKABE, TAKAYOSHI, KIM, SUN HEE, SUZUKI, HIDEO, TANAKA, NOBUO

Journal:

The Journal of Antibiotics

Year:

1985

Language:

english

File:

PDF, 3.79 MB

english, 1985

48

Lactoquinomycin, a novel anticancer antibiotic. I. Taxonomy, isolation and biological activity.

TANAKA, NOBUO, OKABE, TAKAYOSHI, ISONO, FUJIO, KASHIWAGI, MASAMI, NOMOTO, KUNIKO, TAKAHASHI, MASAKO, SHIMAZU, AKIRA, NISHIMURA, TOSHIO

Journal:

The Journal of Antibiotics

Year:

1985

Language:

english

File:

PDF, 2.52 MB

english, 1985

49

Biological activity of cadeguomycin. Inhibition of tumor growth and metastasis, immunostimulation, and potentiation of 1-.BETA.-D-arabinofuranosylcytosine.

YUAN, BAO DING, WU, RONG TSUN, SATO, ISAO, OKABE, TAKAYOSHI, SUZUKI, HIDEO, NISHIMURA, TOSHIO, TANAKA, NOBUO

Journal:

The Journal of Antibiotics

Year:

1985

Language:

english

File:

PDF, 3.07 MB

english, 1985

50

Effects of cadeguomycin on cytotoxicity of cytosine arabinoside and other pyrimidine nucleoside analogs; A comparative study.

KIM, SUN HEE, OKABE, TAKAYOSHI, TANAKA, NOBUO, SUZUKI, HIDEO

Journal:

The Journal of Antibiotics

Year:

1987

Language:

english

File:

PDF, 136 KB

english, 1987